Motif ID: TAL1_TCF{3,4,12}.p2

Z-value: 1.947


Transcription factors associated with TAL1_TCF{3,4,12}.p2:

Gene SymbolEntrez IDGene Name
TAL1 6886 T-cell acute lymphocytic leukemia 1
TCF12 6938 transcription factor 12
TCF3 6929 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
TCF4 6925 transcription factor 4



Activity profile for motif TAL1_TCF{3,4,12}.p2.

activity profile for motif TAL1_TCF{3,4,12}.p2


Sorted Z-values histogram for motif TAL1_TCF{3,4,12}.p2

Sorted Z-values for motif TAL1_TCF{3,4,12}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TAL1_TCF{3,4,12}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_108360798 3.116 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr16_-_67943157 2.927 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr16_+_56286212 2.729 NM_032269
CCDC135
coiled-coil domain containing 135
chr22_+_43451600 2.557 PRR5
proline rich 5 (renal)
chr1_-_176205672 2.523 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr2_+_169367345 2.510 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr9_-_129707392 2.436 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr1_+_32489426 2.118 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr2_-_233586145 2.117 NGEF
neuronal guanine nucleotide exchange factor
chr12_-_101835183 2.110 PAH
phenylalanine hydroxylase
chr19_+_40224480 2.037 HPN
hepsin
chr22_+_22907443 2.004 NM_019601
SUSD2
sushi domain containing 2
chr17_+_38256886 1.948


chr2_-_233586164 1.881 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chrX_-_154216929 1.807 NM_001289
CLIC2
chloride intracellular channel 2
chr10_-_73518772 1.790 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr12_-_101835026 1.706 PAH
phenylalanine hydroxylase
chr12_-_101835510 1.652 NM_000277
PAH
phenylalanine hydroxylase
chr7_+_94953148 1.648 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr22_+_38652555 1.647 GRAP2
GRB2-related adaptor protein 2
chr22_+_22907417 1.614 SUSD2
sushi domain containing 2
chr19_-_44060729 1.576 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr2_-_158008763 1.569 NM_004288
CYTIP
cytohesin 1 interacting protein
chr6_-_30188845 1.557 NM_007028
TRIM31
tripartite motif containing 31
chr2_-_55131157 1.438 RTN4
reticulon 4
chr2_-_55131176 1.411 RTN4
reticulon 4
chr17_+_38256710 1.332 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr22_-_34930705 1.303 NM_030643
NM_145660
APOL4

apolipoprotein L, 4

chr17_-_53761119 1.289 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr2_-_55131202 1.278 NM_020532
NM_153828
NM_207520
RTN4


reticulon 4


chr2_-_55131124 1.255 RTN4
reticulon 4
chr16_-_29817841 1.251 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr16_+_11966464 1.218 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr14_-_93493519 1.183 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr6_-_66473790 1.170 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr19_-_38052481 1.169 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr8_+_21967008 1.160 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr6_-_41811916 1.155 NM_001167827
TFEB
transcription factor EB
chrX_+_46825179 1.151 RGN
regucalcin (senescence marker protein-30)
chr3_+_134976965 1.135 TF
transferrin
chr1_+_179164195 1.087


chr1_-_224143389 1.066 NM_020997
LEFTY1
left-right determination factor 1
chr14_-_93919305 1.048 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr19_+_17499064 1.029 FAM129C
family with sequence similarity 129, member C
chr10_+_44726635 1.008 NM_001123376
TMEM72
transmembrane protein 72
chr19_+_58239802 0.997 NM_001191055
HERV-V2
envelope glycoprotein ENVV2
chr7_+_138695236 0.990 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr2_-_25320299 0.978 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr17_-_43390108 0.965 NM_024320
PRR15L
proline rich 15-like
chr2_-_188086612 0.938 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr6_+_167456230 0.925 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr2_-_55130925 0.922 RTN4
reticulon 4
chr22_+_23309717 0.919 NM_013430
GGT1
gamma-glutamyltransferase 1
chr7_+_138695209 0.908 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr2_-_55131096 0.906 RTN4
reticulon 4
chr11_+_5367182 0.892 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr12_+_56114724 0.878 NM_005538
INHBC
inhibin, beta C
chr21_-_33107813 0.855 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr22_+_34979118 0.851 APOL1
apolipoprotein L, 1
chr11_-_68505030 0.837 NM_198923
MRGPRD
MAS-related GPR, member D
chr11_-_66431910 0.836 NM_022172
PC
pyruvate carboxylase
chr2_-_96320185 0.827 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr1_+_50342168 0.813 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr11_-_5212168 0.810 NM_000519
HBD
hemoglobin, delta
chr10_+_11246934 0.808 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr1_+_6537924 0.802 NM_138697
NM_177540
TAS1R1

taste receptor, type 1, member 1

chr7_-_92693716 0.798 NM_001039372
HEPACAM2
HEPACAM family member 2
chr9_+_95886625 0.777 PTPDC1
protein tyrosine phosphatase domain containing 1
chr1_-_6343306 0.772 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr2_-_151854619 0.752 NM_004688
NMI
N-myc (and STAT) interactor
chr7_+_138695241 0.747 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr8_-_81155564 0.729 NM_001025252
TPD52
tumor protein D52
chr17_-_64568641 0.725 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr19_+_4442610 0.701 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr1_+_221168388 0.701 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr2_-_55130963 0.695 RTN4
reticulon 4
chr11_+_66979393 0.671 NM_145200
CABP4
calcium binding protein 4
chr7_+_113853790 0.662 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr10_+_5228756 0.661 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr16_-_29818334 0.660 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chrX_+_46967360 0.659 NM_001170460
CDK16
cyclin-dependent kinase 16
chr10_-_73518315 0.649 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr11_-_614901 0.647 NM_001171968
NM_021924
NM_031264
CDHR5


cadherin-related family member 5


chr3_-_10307408 0.647 NM_001134941
NM_016362
GHRL

ghrelin/obestatin prepropeptide

chr11_+_65164167 0.640 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr1_+_242283129 0.629 NM_006352
ZNF238
zinc finger protein 238
chr10_-_75127559 0.621 NM_001144000
AGAP5
ArfGAP with GTPase domain, ankyrin repeat and PH domain 5
chr9_+_95886558 0.611 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr4_-_185921384 0.611 ACSL1
acyl-CoA synthetase long-chain family member 1
chr16_+_76613912 0.591 NM_005752
CLEC3A
C-type lectin domain family 3, member A
chr12_+_27740694 0.583 NM_001029874
REP15
RAB15 effector protein
chr21_+_17841297 0.559 CXADR
coxsackie virus and adenovirus receptor
chr22_+_34979062 0.559 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr20_-_42457717 0.556


chr2_-_157892391 0.552 NM_001009959
ERMN
ermin, ERM-like protein
chr11_-_57752923 0.551 NM_001004471
OR10Q1
olfactory receptor, family 10, subfamily Q, member 1
chr15_+_56511466 0.515 NM_000236
LIPC
lipase, hepatic
chr3_+_120982020 0.513 NM_003889
NM_033013
NR1I2

nuclear receptor subfamily 1, group I, member 2

chr11_-_116168316 0.513 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr3_-_69381995 0.510 FRMD4B
FERM domain containing 4B
chrX_+_38096679 0.508 NM_000531
OTC
ornithine carbamoyltransferase
chr7_+_138695537 0.508 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr14_-_93829309 0.506 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr6_+_36318922 0.498 NM_173676
NM_001145716
PNPLA1

patatin-like phospholipase domain containing 1

chr19_-_40996040 0.489 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr12_-_52016270 0.486 NM_001173467
SP7
Sp7 transcription factor
chr17_+_53769562 0.485 LOC100506779
hypothetical LOC100506779
chr16_+_4546491 0.479 NM_001145011
LOC342346
hypothetical protein LOC342346
chr18_-_28606839 0.474 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr10_-_74384569 0.473 PLA2G12B
phospholipase A2, group XIIB
chr12_-_6615348 0.466 NM_020400
LPAR5
lysophosphatidic acid receptor 5
chr7_+_94130752 0.466 PEG10
paternally expressed 10
chr16_-_79811475 0.461 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr7_+_138695144 0.460 NM_016019
LUC7L2
LUC7-like 2 (S. cerevisiae)
chr1_+_156842852 0.455 NM_001004478
OR10Z1
olfactory receptor, family 10, subfamily Z, member 1
chr17_-_9863929 0.453 GAS7
growth arrest-specific 7
chr1_+_205329206 0.451 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr10_-_74384485 0.445 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr10_+_85994788 0.436 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr1_+_50344550 0.435 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr4_+_39084936 0.425 KLB
klotho beta
chr12_+_61240542 0.422 MON2
MON2 homolog (S. cerevisiae)
chr2_-_183611470 0.422 NM_013436
NM_205842
NCKAP1

NCK-associated protein 1

chr1_+_108904493 0.420 NM_001010883
FAM102B
family with sequence similarity 102, member B
chr1_-_218286476 0.410 EPRS
glutamyl-prolyl-tRNA synthetase
chr1_-_38185312 0.408 NM_005540
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr22_-_34886727 0.404 NM_145640
APOL3
apolipoprotein L, 3
chr1_+_205328834 0.401 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr19_-_12858956 0.400 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr10_-_69267774 0.398 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr1_-_205272619 0.398 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr10_+_89257569 0.397 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr12_-_53064723 0.396 NM_015481
ZNF385A
zinc finger protein 385A
chr8_+_110443881 0.395 NM_177531
PKHD1L1
polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
chr17_+_35471971 0.387 NM_001190919
THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
chr17_+_40594046 0.387 NM_144608
HEXIM2
hexamthylene bis-acetamide inducible 2
chr17_-_59342319 0.380 NM_001318
NM_022579
NM_022580
NM_022581
CSHL1



chorionic somatomammotropin hormone-like 1



chr5_+_139856688 0.380 ANKHD1
ankyrin repeat and KH domain containing 1
chr10_+_85923473 0.379 NM_207373
C10orf99
chromosome 10 open reading frame 99
chr20_-_44612619 0.378 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr8_-_68821131 0.377 NM_020361
CPA6
carboxypeptidase A6
chr1_-_158948176 0.375 NM_001778
CD48
CD48 molecule
chr17_+_6599879 0.374 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr12_+_99274987 0.372 NM_001145288
NM_139319
SLC17A8

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

chr10_-_98311813 0.371 TM9SF3
transmembrane 9 superfamily member 3
chr12_+_53005177 0.369 NM_016057
COPZ1
coatomer protein complex, subunit zeta 1
chr6_-_41811323 0.369 TFEB
transcription factor EB
chr7_+_129807467 0.369 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr4_+_39084867 0.368 NM_175737
KLB
klotho beta
chr19_-_11549484 0.365 ACP5
acid phosphatase 5, tartrate resistant
chr6_-_31622372 0.363 ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr3_-_180467483 0.360 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr8_-_12220195 0.360 NM_001195257
NM_001037804
LOC100133267
DEFB130
defensin, beta 130-like
defensin, beta 130
chrX_-_55037235 0.359 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr7_-_36992221 0.358 NM_130442
ELMO1
engulfment and cell motility 1
chr5_-_88235624 0.354 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr6_-_11490487 0.346 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr7_+_72883128 0.346 NM_001305
CLDN4
claudin 4
chr1_-_177106702 0.346 NM_004673
ANGPTL1
angiopoietin-like 1
chr6_-_29431950 0.344 NM_030876
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr6_-_29451042 0.343 NM_030959
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr22_-_41672990 0.340 NM_007229
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr19_-_11549441 0.338 ACP5
acid phosphatase 5, tartrate resistant
chr2_-_65013070 0.334 LOC400958
hypothetical LOC400958
chr3_-_196792274 0.334 NM_001647
APOD
apolipoprotein D
chr11_-_71424614 0.334


chr2_-_240618518 0.334 NM_001005853
OR6B2
olfactory receptor, family 6, subfamily B, member 2
chr6_-_30236667 0.333 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr4_-_116254381 0.333 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr12_+_115481568 0.333 NM_001085481
MAP1LC3B2
microtubule-associated protein 1 light chain 3 beta 2
chr6_-_163068749 0.330 PARK2
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
chr11_+_5558682 0.328 NM_001005162
OR52B6
olfactory receptor, family 52, subfamily B, member 6
chr4_+_73123712 0.327 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr10_+_7785347 0.324 ITIH2
inter-alpha (globulin) inhibitor H2
chr9_-_99746923 0.321 NM_018437
HEMGN
hemogen
chr19_+_61624 0.318 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr10_+_7785331 0.318 ITIH2
inter-alpha (globulin) inhibitor H2
chrX_-_111809929 0.316 NM_178175
LHFPL1
lipoma HMGIC fusion partner-like 1
chrX_-_55074125 0.315 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr11_-_65182411 0.312 RELA
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr13_+_107720206 0.311 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr16_-_70168449 0.308 NM_000353
TAT
tyrosine aminotransferase
chr5_-_169657395 0.304 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr1_-_176205970 0.304 SEC16B
SEC16 homolog B (S. cerevisiae)
chr21_+_44844924 0.302 NM_198689
KRTAP10-7
keratin associated protein 10-7
chr17_-_44641741 0.302 NM_031498
NM_001198755
NM_001198756
GNGT2


guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2


chr13_+_107720475 0.301 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr1_-_246789396 0.296 NM_001004694
OR2T29
OR2T5
olfactory receptor, family 2, subfamily T, member 29
olfactory receptor, family 2, subfamily T, member 5
chr20_-_30795463 0.294 NM_001099339
NM_053041
COMMD7

COMM domain containing 7

chr7_+_127020924 0.294 NM_020369
FSCN3
fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)
chr9_+_114376709 0.292 KIAA1958
KIAA1958
chr2_+_136005423 0.291 NM_015361
R3HDM1
R3H domain containing 1
chr11_-_16454493 0.290 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr1_-_24179326 0.288 SRSF10
serine/arginine-rich splicing factor 10
chr1_-_169888373 0.287 NM_000261
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr20_-_36191623 0.287 TGM2
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr9_-_14712669 0.285 NM_005454
CER1
cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)
chr11_+_5610060 0.280 NM_130390
TRIM34
tripartite motif containing 34
chr13_+_107719977 0.279 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr5_-_180560535 0.277 NM_203297
TRIM7
tripartite motif containing 7

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.09 2.10e-10 GO:0007608 sensory perception of smell
3.85 3.32e-10 GO:0007606 sensory perception of chemical stimulus
2.77 7.73e-08 GO:0007600 sensory perception
2.17 3.63e-06 GO:0050877 neurological system process
1.85 5.98e-04 GO:0003008 system process
1.31 1.00e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.44 4.73e-04 GO:0005886 plasma membrane
1.43 6.17e-04 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.29 1.15e-11 GO:0004984 olfactory receptor activity
2.83 2.05e-09 GO:0004930 G-protein coupled receptor activity
2.37 9.32e-09 GO:0004888 transmembrane receptor activity
2.12 1.82e-08 GO:0004872 receptor activity
1.87 1.86e-06 GO:0004871 signal transducer activity
1.87 1.86e-06 GO:0060089 molecular transducer activity